Well it seems as if Einstein’s proposition that all laws of physics hold true in all frames of reference may not be as right as we first though. It seems that alpha, a coupling constant for the electromagnetic force, varies in size from one side of the universe to the other. It also seems that the other constants dealing with the other forces are not constant either. The implications of this are immense, not only does it mean that our understanding of the universe may be restricted to just our local neighborhood, but also that life (or carbon based life) would only be possible in areas where the constants allow for the generation of carbon and oxygen in stars. Even a small variation in the constants would mean that larger nuclei couldn't form. Something else interesting is that this could prove good for string theory, as string theory suggests and can deal with the varying ‘constants’. EDIT: Here is a link to just one article, it's a bit old but hey, it's something. http://www.physorg.com/news202921592.html
In layman terms, Einstein said the physical laws - atom binding, gravity, time and temperature - are the same across the universe. However, Earth's long range sensors have begun to detect variations that shouldn't be - blackholes with no gravitational pull, twin stars with different temperatures and wobbly astral bodies. It's likely that even even the most perfect scientific formula - E=MC little 2 - will need to change. This is a huge challenge for Physicists but, much like Newton had to change when Einstein proved gravity is different according to time, it will need to be done. Time for someone to make a name for themselves.